Role of indole derivative SS-68 in increasing the frequency range of cardiac rhythm control (reflex stimulation of the sinoatrial node)

Introduction: Cardiac pacing is indicated for sick sinus syndrome. It performed with a pacemaker via electrodes implanted in the heart. This technique has several disadvantages. The search alternative methods of cardiac underway. One them control heart rhythm through stimulation tragus.
 Objective: To perform reflex sinoatrial node and to study influence SS-68 substance on it.
 Materials methods: Two were fixed reflexogenic zone rabbits’ auricles, volleys electrical impulses from an stimulator applied electrodes, synchronization range volley frequency contractions was recorded. re-recorded again after injecting (2-phenyl-1-(3-pyrrolidine-1-cyclopropyl)-1H-indole hydrochloride) intravenously at dose 50 µg/kg. In other experiments frogs high-frequency electromagnetic field, process excitation area medulla oblongata associated visualized. After application (50 μM) surface this zone, its recorded.
 Results discussion: Stimulation auricular rabbits produced rate 173.5 ± 2.0 214.0 1.8 per minute. extended 168.2 1.9 219.4 1.5 frog’s oblongata, synchronous glowed field. increased glow by 131.0%.
 Conclusion: increases activating node. main point oblongata. Glow field reflects neuron excitation. increase under indicates synchronously excited neurons, which leads assimilation central generation